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Article

Type 1 diabetes genetic risk score variation across ancestries using whole genome sequencing and array-based approaches.

Scientific reports - 28 Dec 2024

Arni Ankit M, Fraser Diane P, Sharp Seth A, Oram Richard A, Johnson Matthew B, Weedon Michael N, Patel Kashyap A

Abstract excerpt

A Type 1 Diabetes Genetic Risk Score (T1DGRS) aids diagnosis and prediction of Type 1 Diabetes (T1D). While traditionally derived from imputed array genotypes, Whole Genome Sequencing (WGS) provides a more direct approach and is now increasingly used in clinical and research studies. We investigated the concordance between WGS-based and array-based T1DGRS across genetic ancestries in 149,265 UK Biobank...

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Share to Diabetes Mellitus, Type 1
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Risk Score

Share to Genome, Human

Share to Genome-Wide Association Study

Share to Polymorphism, Single Nucleotide

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Share to Whole Genome Sequencing

Source

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Identifiers

PMID: 39730838
DOI: 10.1038/s41598-024-82278-x
PMCID: PMC11680773

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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