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Article

CTCF-binding elements mediate control of V(D)J recombination.

Nature - 11 Sept 2011

Guo Chunguang, Yoon Hye Suk, Franklin Andrew, Jain Suvi, Ebert Anja, Cheng Hwei-Ling, Hansen Erica, Despo Orion, Bossen Claudia, Vettermann Christian, Bates Jamie G, Richards Nicholas, Myers Darienne, Patel Harin, Gallagher Michael, Schlissel Mark S, Murre Cornelis, Busslinger Meinrad, Giallourakis Cosmas C, Alt Frederick W

Abstract excerpt

Immunoglobulin heavy chain (IgH) variable region exons are assembled from V(H), D and J(H) gene segments in developing B lymphocytes. Within the 2.7-megabase mouse Igh locus, V(D)J recombination is regulated to ensure specific and diverse antibody repertoires. Here we report in mice a key Igh V(D)J recombination regulatory region, termed intergenic control region 1 (IGCR1), which lies between the V(H) and D...

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Share to CCCTC-Binding Factor
Share to Chromosomes, Mammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Intergenic

Share to Feedback, Physiological

Share to Gene Rearrangement, B-Lymphocyte, Heavy Chain

Share to Immunoglobulin Heavy Chains

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Share to Thymus Gland

Source

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Identifiers

PMID: 21909113
DOI: 10.1038/nature10495
PMCID: PMC3342812

Genes

CTCF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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CTCF-binding elements mediate control of V(D)J recombination.PMID 21909113Read ↗

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