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Article

Genome-wide pleiotropy analysis of longitudinal blood pressure and harmonized cognitive performance measures.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Sept 2025

Kang Moonil, Ang Ting Fang Alvin, Devine Sherral A, Sherva Richard, Mukherjee Shubhabrata, Trittschuh Emily H, Scollard Phoebe, Lee Michael, Choi Seo-Eun, Klinedinst Brandon, Nakano Connie, Dumitrescu Logan C, Hohman Timothy J, Cuccaro Michael L, Saykin Andrew J, Kukull Walter A, Bennett David A, Wang Li-San, Mayeux Richard P, Haines Jonathan L, Pericak-Vance Margaret A, Schellenberg Gerard D, Crane Paul K, Au Rhoda, Lunetta Kathryn L, Mez Jesse, Farrer Lindsay A

Abstract excerpt

INTRODUCTION: Identifying pleiotropy for blood pressure (BP) and cognitive performance measures may indicate mechanistic links between hypertension and Alzheimer's disease (AD). METHODS: We performed a pleiotropy genome-wide association study (GWAS) for paired measures of systolic, diastolic, pulse, and mean arterial pressure with memory, executive function, and language scores using 116,075 exam data from 25,726...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40951946
DOI: 10.1002/alz.70681
PMCID: PMC12434708

Genes

ADAMTS3
RTN4
SORBS2
SUFU
GATA3
JPH2
PAX2
ULK2
ACTR1A
HIF1AN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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