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Article

Shared genetic aetiology between cognitive functions and physical and mental health in UK Biobank (N=112 151) and 24 GWAS consortia.

Molecular psychiatry - 1 Nov 2016

Hagenaars S P, Harris S E, Davies G, Hill W D, Liewald D C M, Ritchie S J, Marioni R E, Fawns-Ritchie C, Cullen B, Malik R, Worrall B B, Sudlow C L M, Wardlaw J M, Gallacher J, Pell J, McIntosh A M, Smith D J, Gale C R, Deary I J

Abstract excerpt

Causes of the well-documented association between low levels of cognitive functioning and many adverse neuropsychiatric outcomes, poorer physical health and earlier death remain unknown. We used linkage disequilibrium regression and polygenic profile scoring to test for shared genetic aetiology between cognitive functions and neuropsychiatric disorders and physical health. Using information provided by many...

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PMID: 26809841
DOI: 10.1038/mp.2015.225
PMCID: PMC5078856

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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