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Article

Genome-wide pleiotropic analysis identifies shared genetic architecture within the cognition-immune nexus.

Translational psychiatry - 1 Jul 2026

Yu Tong, Zhao Guorui, Zhang Yuyanan, Sun Yaoyao, Lu Zhe, Yuan Rui, Zhu Yunqing, Kang Zhewei, Feng Xiaoyang, Sun Junyuan, Guo Jing, Yang Yang, Yue Weihua

Abstract excerpt

Increasing evidence supports associations between cognitive function and autoimmune disorders, yet the underlying genetic mechanisms remain unclear. Using large-scale genome-wide association statistics for seven cognitive traits and fifteen autoimmune disorders, together with two independent cohorts comprising 522 healthy individuals and 80 patients with schizophrenia, we performed multi-level pleiotropic...

Read the complete abstract on PubMed

Topics

Humans
Genome-Wide Association Study
Genetic Pleiotropy
Autoimmune Diseases
Schizophrenia
Cognition

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Mendelian Randomization Analysis

Genetic Risk Score

Polymorphism, Single Nucleotide

Adult

Female

Multifactorial Inheritance

Male

Source

Open in PubMed Open full text

Identifiers

PMID: 42386713
DOI: 10.1038/s41398-026-04175-3
PMCID: PMC13590498

Genes

AMT
CD33
CRAT
ERAP2
ERBB3
GNL3
MAPK3
MST1R
RPS26
SH2B1
SULT1A1
SULT1A2
TMEM258

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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