Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-wide pleiotropy analysis identifies novel blood pressure variants and improves its polygenic risk scores.

Genetic epidemiology - 1 Mar 2022

Zhu Xiaofeng, Zhu Luke, Wang Heming, Cooper Richard S, Chakravarti Aravinda

Abstract excerpt

Systolic and diastolic blood pressure (S/DBP) are highly correlated modifiable risk factors for cardiovascular disease (CVD). We report here a bidirectional Mendelian Randomization (MR) and horizontal pleiotropy analysis of S/DBP summary statistics from the UK Biobank (UKB)-International Consortium for Blood Pressure (ICBP) (UKB-ICBP) BP genome-wide association study and construct a composite genetic risk score...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Pressure
Share to Genetic Associations and Epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Pleiotropy

Share to Genome-Wide Association Study

Share to Hypertension

Share to Mendelian Randomization Analysis

Share to Polymorphism, Single Nucleotide

Share to Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 34989438
DOI: 10.1002/gepi.22440
PMCID: PMC8863647

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide pleiotropy analysis identifies novel blood pressure variants and improves its polygenic risk scores.PMID 34989438Read ↗

Genome-wide pleiotropy analysis identifies novel blood pressure variants and improves its polygenic risk scoresSemantic proximity Read ↗

Genome Wide Pleiotropic Analysis to Identify Novel Variants and Improve Genetic Risk Score ConstructionSemantic proximity Read ↗

Genome-wide analysis in over 1 million individuals reveals over 2,000 independent genetic signals for blood pressureSemantic proximity Read ↗

Over 1000 genetic loci influencing blood pressure with multiple systems and tissues implicatedSemantic proximity Read ↗

Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.Semantic proximity Read ↗

Blood Pressure and Risk of Cardiovascular Disease in UK Biobank: A Mendelian Randomization Study.Semantic proximity Read ↗

Genome-wide pleiotropy analysis of longitudinal blood pressure and harmonized cognitive performance measuresSemantic proximity Read ↗

Genetic Variation in Blood Pressure and Lifetime Risk of Peripheral Artery Disease: A Mendelian Randomization StudySemantic proximity Read ↗

Identification of multi-omic pleiotropy factors for peripheral artery diseaseSemantic proximity Read ↗

Genetic effects and causal association analyses of 14 common conditions/diseases in multimorbidity patterns.Semantic proximity Read ↗

Identifying common genetic variants in blood pressure due to polygenic pleiotropy with associated phenotypes.Semantic proximity Read ↗

Discovering patterns of pleiotropy in genome-wide association studiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.