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Article

Multi-trait association studies discover pleiotropic loci between Alzheimer's disease and cardiometabolic traits.

Alzheimer's research & therapy - 4 Feb 2021

Bone William P, Siewert Katherine M, Jha Anupama, Klarin Derek, Damrauer Scott M, Chang Kyong-Mi, Tsao Philip S, Assimes Themistocles L, Ritchie Marylyn D, Voight Benjamin F

Abstract excerpt

BACKGROUND: Identification of genetic risk factors that are shared between Alzheimer's disease (AD) and other traits, i.e., pleiotropy, can help improve our understanding of the etiology of AD and potentially detect new therapeutic targets. Previous epidemiological correlations observed between cardiometabolic traits and AD led us to assess the pleiotropy between these traits. METHODS: We performed a set of...

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Identifiers

PMID: 33541420
DOI: 10.1186/s13195-021-00773-z
PMCID: PMC7860582

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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