Article

Genome-wide pleiotropy analysis identifies novel blood pressure variants and improves its polygenic risk scores

2021-09-12

Abstract excerpt

Systolic and diastolic blood pressure (S/DBP) are highly correlated modifiable risk factors for cardiovascular disease (CVD). We report here a bidirectional Mendelian Randomization (MR) and pleiotropy analysis of systolic and diastolic blood pressure (BP) summary statistics from the UKB-ICBP BP genome-wide association study (GWAS) and construct a composite genetic risk score (GRS) by including pleiotropic variants...

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Literature Corpus work: 9565add2-812d-5983-b38e-e60398b3fc90
DOI: 10.1101/2021.09.08.21263225

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