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Article

Polygenic risk and pleiotropy in neurodegenerative diseases.

Neurobiology of disease - 1 Aug 2020

Bellou Eftychia, Stevenson-Hoare Joshua, Escott-Price Valentina

Abstract excerpt

In this paper we explore the phenomenon of pleiotropy in neurodegenerative diseases, focusing on Alzheimer's disease (AD). We summarize the various techniques developed to investigate pleiotropy among traits, elaborating in the polygenic risk scores (PRS) analysis. PRS was designed to assess a cumulative effect of a large number of SNPs for association with a disease and, later for disease risk prediction. Since...

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Identifiers

PMID: 32445791
DOI: 10.1016/j.nbd.2020.104953
PMCID: PMC7378564

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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