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Article

Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer's disease.

Alzheimer's research & therapy - 20 Feb 2018

Chung Jaeyoon, Zhang Xiaoling, Allen Mariet, Wang Xue, Ma Yiyi, Beecham Gary, Montine Thomas J, Younkin Steven G, Dickson Dennis W, Golde Todd E, Price Nathan D, Ertekin-Taner Nilüfer, Lunetta Kathryn L, Mez Jesse, Mayeux Richard, Haines Jonathan L, Pericak-Vance Margaret A, Schellenberg Gerard, Jun Gyungah R, Farrer Lindsay A

Abstract excerpt

BACKGROUND: Simultaneous consideration of two neuropathological traits related to Alzheimer's disease (AD) has not been attempted in a genome-wide association study. METHODS: We conducted genome-wide pleiotropy analyses using association summary statistics from the Beecham et al. study (PLoS Genet 10:e1004606, 2014) for AD-related neuropathological traits, including neuritic plaque (NP), neurofibrillary tangle...

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Identifiers

PMID: 29458411
DOI: 10.1186/s13195-018-0349-z
PMCID: PMC5819208

Genes

HDAC9
ECRG4
TRAPPC12
ADI1

Provenance

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