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Article

Structural insights into DdCBE in action enable high-precision mitochondrial DNA editing.

Molecular cell - 18 Sept 2025

Xiang Jiangchao, Xu Wenchao, Wu Jing, Luo Yaxin, Liu Chengyu, Hou Yaofeng, Chen Jia, Yang Bei

Abstract excerpt

DddA-derived cytosine base editor (DdCBE) couples transcription activator-like effector (TALE) arrays and the double-stranded DNA (dsDNA)-specific cytidine deaminase DddA to target mitochondrial DNA (mtDNA) for editing. However, structures of DdCBE in action are unavailable, impeding its mechanistic-based optimization for high-precision-demanding therapeutic applications. Here, we determined the cryo-electron...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40934924
DOI: 10.1016/j.molcel.2025.08.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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