Article

MitoEdit: a pipeline for optimizing mtDNA base editing and predicting bystander effects

2025-01-25

Abstract excerpt

<h4>Short Structured Abstract</h4> <h4>Motivation</h4> Human mitochondrial DNA (mtDNA) mutations are causally implicated in maternally inherited mitochondrial respiratory disorders; however, the role of somatic mtDNA mutations in both late-onset chronic diseases and cancer remains less clear. Although recent advances in mtDNA base editing technology have the potential to model and characterize many of these muta...

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Literature Corpus work: beb12948-33e9-5ff6-a517-55cf88381bd4
DOI: 10.1101/2025.01.22.634390

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