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Article

Developing mitochondrial base editors with diverse context compatibility and high fidelity via saturated spacer library.

Nature communications - 19 Oct 2023

Sun Haifeng, Wang Zhaojun, Shen Limini, Feng Yeling, Han Lu, Qian Xuezhen, Meng Runde, Ji Kangming, Liang Dong, Zhou Fei, Lou Xin, Zhang Jun, Shen Bin

Abstract excerpt

DddA-derived cytosine base editors (DdCBEs) greatly facilitated the basic and therapeutic research of mitochondrial DNA mutation diseases. Here we devise a saturated spacer library and successfully identify seven DddA homologs by performing high-throughput sequencing based screen. DddAs of Streptomyces sp. BK438 and Lachnospiraceae bacterium sunii NSJ-8 display high deaminase activity with a strong GC context...

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Identifiers

PMID: 37857619
DOI: 10.1038/s41467-023-42359-3
PMCID: PMC10587121

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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