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Cytosolic DNA crosstalk in senescence: a new axis of inflammatory signaling?

29 Aug 2025

Abstract excerpt

Cellular senescence is a form of stable growth arrest that contributes to aging and age-related diseases, in part through the senescence-associated secretory phenotype (SASP). Recent studies show that senescent cells accumulate several species of cytosolic DNAs, including mitochondrial DNA (mtDNA), cytoplasmic chromatin fragments (CCFs), and retrotransposable element cDNAs, which collectively activate the...

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PMID: 40883506
DOI: 10.1038/s44318-025-00531-z

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