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Article

Cellular senescence and senescence-associated secretory phenotype via the cGAS-STING signaling pathway in cancer.

Cancer science - 1 Feb 2020

Loo Tze Mun, Miyata Kenichi, Tanaka Yoko, Takahashi Akiko

Abstract excerpt

Cellular senescence is historically regarded as a tumor suppression mechanism to prevent damaged cells from aberrant proliferation in benign and premalignant tumors. However, recent findings have suggested that senescent cells contribute to tumorigenesis and age-associated pathologies through the senescence-associated secretory phenotype (SASP). Therefore, to control age-associated cancer, it is important to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31799772
DOI: 10.1111/cas.14266
PMCID: PMC7004529

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