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Article

Sensing the Breaks: Cytosolic Chromatin in Senescence and Cancer.

Trends in molecular medicine - 1 Dec 2017

Di Micco Raffaella

Abstract excerpt

Cellular senescence constitutes a stable growth arrest characterized by DNA damage response (DDR) activation and by the senescence-associated secretory phenotype (SASP). SASP, through its paracrine effects, stimulates the immune system for senescence eradication. Similarly, chemotherapy-treated cancers activate an interferon-mediated response to induce anti-tumor immunity. Recent studies now uncover a new role...

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Identifiers

PMID: 29133134
DOI: 10.1016/j.molmed.2017.10.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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