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Article

Chromatin basis of the senescence-associated secretory phenotype.

Trends in cell biology - 1 Jun 2022

Hao Xue, Wang Chen, Zhang Rugang

Abstract excerpt

Cellular senescence is a stable cell growth arrest. Senescent cells are metabolically active, as exemplified by the secretion of inflammatory cytokines, chemokines, and growth factors, which is termed senescence-associated secretory phenotype (SASP). The SASP exerts a range of functions in both normal health and pathology, which is possibly best characterized in cancers and physical aging. Recent studies...

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PMID: 35012849
DOI: 10.1016/j.tcb.2021.12.003
PMCID: PMC9106822

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