Article
Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells.
Nature communications - 28 Mar 2018
Takahashi Akiko, Loo Tze Mun, Okada Ryo, Kamachi Fumitaka, Watanabe Yoshihiro, Wakita Masahiro, Watanabe Sugiko, Kawamoto Shimpei, Miyata Kenichi, Barber Glen N, Ohtani Naoko, Hara Eiji
Abstract excerpt
Accumulating evidence indicates that the senescence-associated secretory phenotype (SASP) contributes to many aspects of physiology and disease. Thus, controlling the SASP will have tremendous impacts on our health. However, our understanding of SASP regulation is far from complete. Here, we show that cytoplasmic accumulation of nuclear DNA plays key roles in the onset of SASP. Although both DNase2 and TREX1...
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