Article

STING promotes homeostatic maintenance of tissues and confers longevity with aging

2024-04-08

Abstract excerpt

<h4>SUMMARY</h4> Local immune processes within aging tissues are a significant driver of aging associated dysfunction, but tissue-autonomous pathways and cell types that modulate these responses remain poorly characterized. The cytosolic DNA sensing pathway, acting through cyclic GMP-AMP synthase (cGAS) and Stimulator of Interferon Genes (STING), is broadly expressed in tissues, and is poised to regulate local ty...

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Literature Corpus work: b4254715-c668-546a-bf90-4f3c082ae238
DOI: 10.1101/2024.04.04.588107

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