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Article

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence.

Nature cell biology - 1 Sept 2017

Glück Selene, Guey Baptiste, Gulen Muhammet Fatih, Wolter Katharina, Kang Tae-Won, Schmacke Niklas Arndt, Bridgeman Anne, Rehwinkel Jan, Zender Lars, Ablasser Andrea

Abstract excerpt

Cellular senescence is triggered by various distinct stresses and characterized by a permanent cell cycle arrest. Senescent cells secrete a variety of inflammatory factors, collectively referred to as the senescence-associated secretory phenotype (SASP). The mechanism(s) underlying the regulation of the SASP remains incompletely understood. Here we define a role for innate DNA sensing in the regulation of...

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Identifiers

PMID: 28759028
DOI: 10.1038/ncb3586
PMCID: PMC5826565

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