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Cytosolic Self-DNA—A Potential Source of Chronic Inflammation in Aging

15 Dec 2021

Abstract excerpt

Aging is the consequence of a lifelong accumulation of stochastic damage to tissues and cellular components. Advancing age closely associates with elevated markers of innate immunity and low-grade chronic inflammation, probably reflecting steady increasing incidents of cellular and tissue damage over the life course. The DNA sensing cGAS-STING signaling pathway is activated by misplaced cytosolic self-DNA, which...

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PMID: 34944052
DOI: 10.3390/cells10123544

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