Article
Whole-genome sequencing reveals rare and structural variants contributing to psoriasis and identifies CERCAM as a risk gene.
Cell genomics - 8 Oct 2025
Sonehara Kyuto, Watanabe Rei, Matsumura Yutaka, Mitsui Yuichi, Ogawa Yosuke, Odomari Kaori, Sakaue Saori, Namba Shinichi, Komuro Mariko, Edamoto Mio, Watanabe Junya, Hirota Tomomitsu, Arase Noriko, Nakamura Yuumi, Nakajima Kimiko, Okamoto Takashi, Nishikawa Rika, Yamamoto Kenichi, Suzuki Ken, Kishikawa Toshihiro, Edahiro Ryuya, Shirai Yuya, Naito Tatsuhiko, Sasa Noah, Ishitsuka Yosuke, Furuta Junichi, Kunimoto Kayo, Kajihara Ikko, Fukushima Satoshi, Miyachi Hideaki, Matsue Hiroyuki, Kamata Masahiro, Momose Mami, Miyagawa Ippei, Tanaka Hiroaki, Ueno Masanobu, Bito Toshinori, Nagai Hiroshi, Ikeda Tetsuya, Horikawa Tatsuya, Adachi Atsuko, Matsubara Tsukasa, Nishida Emi, Matsuda Koichi, Shojima Nobuhiro, Nakagawa Ikuma, Asano Yoshihide, Sato Shinichi, Imafuku Shinichi, Tada Yayoi, Nishigori Chikako, Jinnin Masatoshi, Ihn Hironobu, Asahina Akihiko, Saeki Hidehisa, Yamauchi Toshimasa, Kadowaki Takashi, Kawamura Tatsuyoshi, Shimada Shinji, Katayama Ichiro, Higasa Koichiro, Noguchi Emiko, Sano Shigetoshi, Tanaka Yoshiya, Matsuda Fumihiko, Kumanogoh Atsushi, Tamari Mayumi, Satoh Takashi, Fujimoto Manabu, Morita Akimichi, Okada Yukinori
Abstract excerpt
Psoriasis vulgaris (PsV) is an immune-mediated inflammatory skin disorder with complex genetic architecture. Most genome-wide association studies (GWASs) of PsV have been limited to analyzing common single-nucleotide variants in Europeans, lacking diversity in the variant spectrum and ancestral background. To investigate the contribution of rare variants (RVs) and structural variants (SVs), we perform a...
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