Article
Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis.
Nature communications - 9 Apr 2015
Zuo Xianbo, Sun Liangdan, Yin Xianyong, Gao Jinping, Sheng Yujun, Xu Jinhua, Zhang Jianzhong, He Chundi, Qiu Ying, Wen Guangdong, Tian Hongqing, Zheng Xiaodong, Liu Shengxiu, Wang Wenjun, Li Weiran, Cheng Yuyan, Liu Longdan, Chang Yan, Wang Zaixing, Li Zenggang, Li Longnian, Wu Jianping, Fang Ling, Shen Changbing, Zhou Fusheng, Liang Bo, Chen Gang, Li Hui, Cui Yong, Xu Aie, Yang Xueqin, Hao Fei, Xu Limin, Fan Xing, Li Yuzhen, Wu Rina, Wang Xiuli, Liu Xiaoming, Zheng Min, Song Shunpeng, Ji Bihua, Fang Hong, Yu Jianbin, Sun Yongxin, Hui Yan, Zhang Furen, Yang Rongya, Yang Sen, Zhang Xuejun
Abstract excerpt
Genome-wide association studies (GWASs) have reproducibly associated ∼40 susceptibility loci with psoriasis. However, the missing heritability is evident and the contributions of coding variants have not yet been systematically evaluated. Here, we present a large-scale whole-exome array analysis for psoriasis consisting of 42,760 individuals. We discover 16 SNPs within 15 new genes/loci associated with psoriasis,...
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