Article
Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture.
American journal of human genetics - 3 Dec 2015
Stuart Philip E, Nair Rajan P, Tsoi Lam C, Tejasvi Trilokraj, Das Sayantan, Kang Hyun Min, Ellinghaus Eva, Chandran Vinod, Callis-Duffin Kristina, Ike Robert, Li Yanming, Wen Xiaoquan, Enerbäck Charlotta, Gudjonsson Johann E, Kõks Sulev, Kingo Külli, Esko Tõnu, Mrowietz Ulrich, Reis Andre, Wichmann H Erich, Gieger Christian, Hoffmann Per, Nöthen Markus M, Winkelmann Juliane, Kunz Manfred, Moreta Elvia G, Mease Philip J, Ritchlin Christopher T, Bowcock Anne M, Krueger Gerald G, Lim Henry W, Weidinger Stephan, Weichenthal Michael, Voorhees John J, Rahman Proton, Gregersen Peter K, Franke Andre, Gladman Dafna D, Abecasis Gonçalo R, Elder James T
Abstract excerpt
Psoriasis vulgaris (PsV) is a common inflammatory and hyperproliferative skin disease. Up to 30% of people with PsV eventually develop psoriatic arthritis (PsA), an inflammatory musculoskeletal condition. To discern differences in genetic risk factors for PsA and cutaneous-only psoriasis (PsC), we carried out a genome-wide association study (GWAS) of 1,430 PsA case subjects and 1,417 unaffected control subjects....
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