Article
Genome-wide association meta-analysis identifies 29 new acne susceptibility loci.
Nature communications - 7 Feb 2022
Mitchell Brittany L, Saklatvala Jake R, Dand Nick, Hagenbeek Fiona A, Li Xin, Min Josine L, Thomas Laurent, Bartels Meike, Jan Hottenga Jouke, Lupton Michelle K, Boomsma Dorret I, Dong Xianjun, Hveem Kristian, Løset Mari, Martin Nicholas G, Barker Jonathan N, Han Jiali, Smith Catherine H, Rentería Miguel E, Simpson Michael A
Abstract excerpt
Acne vulgaris is a highly heritable skin disorder that primarily impacts facial skin. Severely inflamed lesions may leave permanent scars that have been associated with long-term psychosocial consequences. Here, we perform a GWAS meta-analysis comprising 20,165 individuals with acne from nine independent European ancestry cohorts. We identify 29 novel genome-wide significant loci and replicate 14 of the 17...
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