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Article

Psoriasis-Associated Late Cornified Envelope (LCE) Proteins Have Antibacterial Activity.

The Journal of investigative dermatology - 1 Nov 2017

Niehues Hanna, Tsoi Lam C, van der Krieken Danique A, Jansen Patrick A M, Oortveld Merel A W, Rodijk-Olthuis Diana, van Vlijmen Ivonne M J J, Hendriks Wiljan J A J, Helder Richard W, Bouwstra Joke A, van den Bogaard Ellen H, Stuart Philip E, Nair Rajan P, Elder James T, Zeeuwen Patrick L J M, Schalkwijk Joost

Abstract excerpt

Terminally differentiating epidermal keratinocytes express a large number of structural and antimicrobial proteins that are involved in the physical barrier function of the stratum corneum and provide innate cutaneous host defense. Late cornified envelope (LCE) genes, located in the epidermal differentiation complex on chromosome 1, encode a family of 18 proteins of unknown function, whose expression is largely...

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Identifiers

PMID: 28634035
DOI: 10.1016/j.jid.2017.06.003
PMCID: PMC5651197

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Psoriasis-Associated Late Cornified Envelope (LCE) Proteins Have Antibacterial Activity.PMID 28634035Read ↗

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