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Article

GRK2 Orchestrates VSMC Phenotypic Modulation via DNMT1-Mediated DNA Methylation Reprogramming.

Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 2025

Kong Chao-Hua, Sun Yue, Wu Li-da, Zhou Wen-Ying, Wang Dong-Chen, Jiang Zi-Hao, Jiang Xiao-Min, Ye Peng, Gu Yue, Chen Ai-Qun, Luo Jin-Que, Chao Yue-Lin, Chen Shao-Liang

Abstract excerpt

BACKGROUND: Vascular smooth muscle cell (VSMC) phenotypic modulation is responsible for the pathogenesis of hyper-muscularized arterial diseases. Recent studies have highlighted the critical role of epigenetic regulation in VSMC fate. However, the mechanisms underlying the precise regulation of the epigenetic machinery in VSMC remain unclear. METHODS: Using mouse aortic smooth muscle cells, carotid artery injury...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA (Cytosine-5-)-Methyltransferase 1

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Share to Epigenesis, Genetic

Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

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Source

Identifiers

PMID: 40836921
DOI: 10.1161/ATVBAHA.125.322645

Genes

GRK2
DNMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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