Article
SGK1-Mediated Vascular Smooth Muscle Cell Phenotypic Transformation Promotes Thoracic Aortic Dissection Progression.
Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2025
Leng Shuai, Li Haijie, Zhang Pengfei, Dang Zhiqiao, Shao Baowei, Xue Shishan, Ning Yansong, Teng Xilong, Zhang Leilei, Wang Honglu, Li Na, Zhang Fengquan, Yu Wenqian
Abstract excerpt
BACKGROUND: The occurrence of thoracic aortic dissection (TAD) is closely related to the transformation of vascular smooth muscle cells (VSMCs) from a contractile to a synthetic phenotype. The role of SGK1 (serum- and glucocorticoid-regulated kinase 1) in VSMC phenotypic transformation and TAD occurrence is unclear. METHODS: Four-week-old male Sgk1F/F (Sgk1 floxed) and Sgk1F/F;TaglnCre (smooth muscle...
Topics
- Animals
- Immediate-Early Proteins
- Muscle, Smooth, Vascular
- Protein Serine-Threonine Kinases
- Aortic Dissection
- Male
- Phenotype
- Myocytes, Smooth Muscle
- Mice, Knockout
- Aortic Aneurysm, Thoracic