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Chromatin Remodeling in VSMC Phenotype Switching During Vascular Remodeling: From Mechanism to Therapeutic Potential.

Biomolecules - 7 Feb 2026

Ma Xiaozhu, Mei Shuai, Wuyun Qidamugai, Zhou Li, Ding Hu, Yan Jiangtao

Abstract excerpt

Vascular remodeling is a characteristic pathological feature of various vascular diseases, including atherosclerosis, restenosis following vascular injury, hypertension, and aneurysms. The phenotypic switching of vascular smooth muscle cells (VSMCs) acts as a key driver of vascular remodeling. Under specific pathological stimuli, VSMCs rapidly transition from a contractile to a dedifferentiated phenotype,...

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Share to Chromatin Assembly and Disassembly
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Histones

Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

Share to Phenotype

Share to Vascular Remodeling

Source

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Identifiers

PMID: 41750335
DOI: 10.3390/biom16020265
PMCID: PMC12937741

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