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DNAscent v2: detecting replication forks in nanopore sequencing data with deep learning

9 Jun 2021

Abstract excerpt

BACKGROUND: Measuring DNA replication dynamics with high throughput and single-molecule resolution is critical for understanding both the basic biology behind how cells replicate their DNA and how DNA replication can be used as a therapeutic target for diseases like cancer. In recent years, the detection of base analogues in Oxford Nanopore Technologies (ONT) sequencing reads has become a promising new method to...

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PMID: 34107894
DOI: 10.1186/s12864-021-07736-6

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