Article
Design and Evaluation of Next-Generation HIV Genotyping for Detection of Resistance Mutations to 28 Antiretroviral Drugs Across 5 Major Classes Including Lenacapavir.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 24 Dec 2025
Park Sung Yong, Takayama Christian, Ryu Jenica, Sattah Martin, Badii Zachariah, Kim Ju Won, Shafer Robert W, Gorbach Pamina M, Lee Ha Youn
Abstract excerpt
BACKGROUND: The emergence and spread of human immunodeficiency virus (HIV) drug-resistant strains present a major barrier to effective lifelong antiretroviral therapy. The anticipated rise in long-acting subcutaneous lenacapavir (LEN) use, along with the increased risk of transmitted resistance and pre-exposure prophylaxis-associated resistance, underscore the urgent need for advanced genotyping methods to...
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