Optimizing HIV-1 Genotypic Resistance Testing for Low- and Middle-Income Countries: High-Impact HIV-1 Mutations Across WHO-Defined Scenarios.

doi:10.3390/v18060588

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Optimizing HIV-1 Genotypic Resistance Testing for Low- and Middle-Income Countries: High-Impact HIV-1 Mutations Across WHO-Defined Scenarios.

Viruses - 22 May 2026

Shafer Robert W, Tao Kaiming, Loosli Tom, Abecasis Ana, Armenia Daniele, Bwire George, Diaz Ricardo Sobhie, Fokam Joseph, Giron Amalia, Inzaule Seth, Kantor Rami, Kityo Cissy, Kouyos Roger D, Kurle Swarali, Marcelin Anne-Genevieve, Paredes Roger, Peeters Martine, Pimentel Victor F, Schapiro Jonathan M, Steegen Kim, Vitoria Marco, Wensing Annemarie M, Parkin Neil, Jordan Michael R

Abstract excerpt

INTRODUCTION: Drug resistance testing may improve the management of people living with HIV (PLWH) in several scenarios in low- and middle-income countries (LMICs). To guide assay development, the WHO published a target product profile (TPP) outlining two priority use cases (scenarios) for genotypic resistance testing: (1) PLWH with confirmed virological failure (VF) on an integrase strand transfer inhibitor...

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PMID: 42357599
DOI: 10.3390/v18060588
PMCID: PMC13307858

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