Extensive diversity and impact of drug-resistant HIV-1 variants in individuals with prior virologic failure.

doi:10.1371/journal.ppat.1014118

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Article

Extensive diversity and impact of drug-resistant HIV-1 variants in individuals with prior virologic failure.

PLoS pathogens - 1 May 2026

Pillay Melendhran, Choudhary Manish C, Deo Rinki, Naumenko Serhiy, Tamura Trevor J, Etemad Behzad, Edelstein Gregory, Khan Aabida, Govender Kerusha, Govender Subitha, Tzou Philip, Mick Mary, Herbert Zachary T, Muyindike Winnie, Moosa Mahomed-Yunus Suleman, Brijkumar Jay, Sunpath Henry, McCluskey Suzanne, Chimukangara Benjamin, Manyana Sontaga C, Gounder Lilishia, Parboosing Raveen, Francois Kerri-Lee, Shafer Robert, Ho Sui Shannan, Pillay Selvan, Marconi Vincent, Siedner Mark J, Moodley Pravi, Msomi Nokukhanya, Li Jonathan Z

Abstract excerpt

HIV-1 drug resistance remains a major challenge to treatment and control efforts, particularly in sub-Saharan Africa (sSA). However, standard resistance genotyping does not adequately capture linked drug resistance mutations within the viral quasispecies that may influence virologic failure (VF). We used a next-generation sequencing primer ID (NGS-Primer ID) assay to characterize linked HIV-1 drug resistance...

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PMID: 42118783
DOI: 10.1371/journal.ppat.1014118
PMCID: PMC13221146

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