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Article

Deep sequencing reveals underestimated burden of integrase inhibitor resistance mutations in people living with HIV: a global individual patient data meta-analysis.

Emerging microbes & infections - 1 Dec 2025

Yuan Defu, Zhao Fei, Liu Yangyang, Liu Shanshan, Yan Hongxia, Liu Lifeng, Zhang Tong, Wang Bei, Su Bin

Abstract excerpt

Integrase strand transfer inhibitors (INSTIs) have emerged as cornerstone agents in global antiretroviral therapy, though growing drug resistance presents clinical challenges. Conventional Sanger sequencing may underestimate the burden of low-frequency variants. This global meta-analysis systematically assesses the actual INSTI resistance burden among people living with HIV (PLWH) through deep sequencing...

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Identifiers

PMID: 41293884
DOI: 10.1080/22221751.2025.2595793
PMCID: PMC12915406

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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