Contribution of allelic imbalance to colorectal cancer.

doi:10.1038/s41467-018-06132-1

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Article

Contribution of allelic imbalance to colorectal cancer.

Nature communications - 10 Sept 2018

Palin Kimmo, Pitkänen Esa, Turunen Mikko, Sahu Biswajyoti, Pihlajamaa Päivi, Kivioja Teemu, Kaasinen Eevi, Välimäki Niko, Hänninen Ulrika A, Cajuso Tatiana, Aavikko Mervi, Tuupanen Sari, Kilpivaara Outi, van den Berg Linda, Kondelin Johanna, Tanskanen Tomas, Katainen Riku, Grau Marta, Rauanheimo Heli, Plaketti Roosa-Maria, Taira Aurora, Sulo Päivi, Hartonen Tuomo, Dave Kashyap, Schmierer Bernhard, Botla Sandeep, Sokolova Maria, Vähärautio Anna, Gladysz Kornelia, Ongen Halit, Dermitzakis Emmanouil, Bramsen Jesper Bertram, Ørntoft Torben Falck, Andersen Claus Lindbjerg, Ristimäki Ari, Lepistö Anna, Renkonen-Sinisalo Laura, Mecklin Jukka-Pekka, Taipale Jussi, Aaltonen Lauri A

Abstract excerpt

Point mutations in cancer have been extensively studied but chromosomal gains and losses have been more challenging to interpret due to their unspecific nature. Here we examine high-resolution allelic imbalance (AI) landscape in 1699 colorectal cancers, 256 of which have been whole-genome sequenced (WGSed). The imbalances pinpoint 38 genes as plausible AI targets based on previous knowledge. Unbiased CRISPR-Cas9...

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Identifiers

PMID: 30202008
DOI: 10.1038/s41467-018-06132-1
PMCID: PMC6131244

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