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Article

PIWI Expression and Function in Cancer

1 Jan 2012

Abstract excerpt

PIWI proteins, a subclade of the Argonaute family proteins, are expressed predominantly in the germline and bind to PIWI-interacting RNAs (piRNAs), which are 25-31 nucleotides in length. The PIWI/piRNA pathway plays critical roles in germline development by regulating transposons and other targets to maintain genome integrity. While the functions of PIWI in the germline have been extensively investigated, recent...

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Identifiers

PMID: 23087701
DOI: 10.3389/fgene.2012.00204

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