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Transposable elements mediate genetic effects altering the expression of nearby genes in colorectal cancer

2024-01-25

Abstract excerpt

Abstract Transposable elements (TEs) are prevalent repeats in the human genome, play a significant role in the regulome, and their disruption can contribute to tumorigenesis. However, TE influence on gene expression in cancer remains unclear. Here, we analyze 275 normal colon and 276 colorectal cancer samples from the SYSCOL cohort, discovering 10,231 and 5,199 TE-expression quantitative trait loci (eQTLs) in norm...

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Literature Corpus work
9452e393-0407-524d-b653-a2504e2d6328
DOI
10.1038/s41467-023-42405-0
Open publication

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Transposable elements mediate genetic effects altering the expression of nearby genes in colorectal cancerDOI 10.1038/s41467-023-42405-0
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