Article
Phenotypic screens reveal Plasmodium falciparum genetic factors associated with infection of sickle-trait cells.
Blood cells, molecules & diseases - 1 Nov 2025
Pires Camilla V, Oberstaller Jenna, Wang Chengqi, Gibbons Justin, Micchelli Chiara, Zhang Min, Otto Thomas D, Rayner Julian C, Taylor Steve, Adams John H
Abstract excerpt
BACKGROUND: Malaria causes over 200 million cases and more than half a million deaths annually. In many African regions, hemoglobinopathies, such as sickle cell trait (HbAS), confer partial protection against severe P. falciparum malaria. HbAS significantly reduces the risk of severe, life-threatening malaria by over 90 %. This study aims to describe a new analysis for the piggyBac transposon-based mutagenesis...
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