Genetic factors regulating Plasmodium falciparum gametocytogenesis identified by phenotypic screens.

doi:10.1038/s41598-024-82133-z

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Article

Genetic factors regulating Plasmodium falciparum gametocytogenesis identified by phenotypic screens.

Scientific reports - 28 Dec 2024

Pires Camilla V, Chawla Jyotsna, Sollelis Lauriane, Oberstaller Jenna, Zhang Min, Wang Chengqi, Gibbons Justin, Rayner Julian C, Otto Thomas D, Marti Matthias, Adams John H

Abstract excerpt

Successful transmission of Plasmodium falciparum from one person to another relies on the complete intraerythrocytic development of non-pathogenic sexual gametocytes infectious for anopheline mosquitoes. Understanding the genetic factors that regulate gametocyte development is vital for identifying transmission-blocking targets in the malaria parasite life cycle. Toward this end, we conducted a forward genetic...

Topics

Plasmodium falciparum
Phenotype
Gametogenesis
Life Cycle Stages
Animals
Protozoan Proteins
Malaria, Falciparum
Humans

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Identifiers

PMID: 39730700
DOI: 10.1038/s41598-024-82133-z
PMCID: PMC11680961

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