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Phenotypic Screens Identify Genetic Factors Associated with Gametocyte Development in the Human Malaria Parasite Plasmodium falciparum.

Microbiology spectrum - 15 Jun 2023

Chawla Jyotsna, Goldowitz Ilana, Oberstaller Jenna, Zhang Min, Pires Camilla Valente, Navarro Francesca, Sollelis Lauriane, Wang Chengqi C Q, Seyfang Andreas, Dvorin Jeffrey, Otto Thomas D, Rayner Julian C, Marti Matthias, Adams John H

Abstract excerpt

Transmission of the deadly malaria parasite Plasmodium falciparum from humans to mosquitoes is achieved by specialized intraerythrocytic sexual forms called gametocytes. Though the crucial regulatory mechanisms leading to gametocyte commitment have recently come to light, networks of genes that control sexual development remain to be elucidated. Here, we report a pooled-mutant screen to identify genes associated...

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Identifiers

PMID: 37154686
DOI: 10.1128/spectrum.04164-22
PMCID: PMC10269797

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Source receipt: pubmed, retrieved 7 Sept 2026.

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