Article
Protein KIC5 is a novel regulator of artemisinin stress response in the malaria parasite Plasmodium falciparum.
Scientific reports - 9 Jan 2023
Simmons Caroline F, Gibbons Justin, Zhang Min, Oberstaller Jenna, Pires Camilla Valente, Casandra Debora, Wang Chengqi, Seyfang Andreas, Otto Thomas D, Rayner Julian C, Adams John H
Abstract excerpt
Artemisinin combination therapies (ACTs) have led to a significant decrease in Plasmodium falciparum malaria mortality. This progress is now threatened by emerging artemisinin resistance (ART-R) linked originally in SE Asia to polymorphisms in the Kelch propeller protein (K13) and more recently to several other seemingly unrelated genetic mutations. To better understand the parasite response to ART, we are...
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