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Article

Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Nature chemical biology - 1 Oct 2009

Yuan Jing, Johnson Ronald L, Huang Ruili, Wichterman Jennifer, Jiang Hongying, Hayton Karen, Fidock David A, Wellems Thomas E, Inglese James, Austin Christopher P, Su Xin-zhuan

Abstract excerpt

Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279 bioactive chemicals. Hundreds of compounds were active in inhibiting parasite growth; 607 differential chemical phenotypes, defined as pairwise IC(50)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19734910
DOI: 10.1038/nchembio.215
PMCID: PMC2784992

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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