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Large-Scale Mutagenesis Screening for Genetic Determinants of Plasmodium falciparum Sexual Development.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2026

Aringbangba Olatunbosun, Pires Camilla Valente, Chawla Jyotsna, Prakash Prem, Sollelis Lauriane, Marti Matthias, Adams John H

Abstract excerpt

To develop effective malaria transmission-blocking vaccines and drugs, it is crucial to understand the genetic factors and molecular mechanisms that regulate the development of Plasmodium blood-stage sexual forms, known as gametocytes-parasite stage capable of surviving in the mosquito vector. We established a scalable forward genetic screen approach using single-insertion mutants generated by random piggyBac...

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PMID: 41479059
DOI: 10.1007/978-1-0716-4985-5_15

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