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Uncovering the essential genes of the human malaria parasite Plasmodium falciparum by saturation mutagenesis

3 May 2018

Abstract excerpt

Saturating malaria mutagenesis Malaria is caused by eukaryotic Plasmodium spp. parasites that classically infect red blood cells. These are difficult organisms to investigate genetically because of their AT-rich genomes. Zhang et al. have exploited this peculiarity by using piggyBac transposon insertion sites to achieve saturation-level mutagenesis for identifying and ranking essential genes and drug targets (see...

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PMID: 29724925
DOI: 10.1126/science.aap7847

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