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Article

Unpacking bedaquiline heteroresistance: the importance of intermediate profiles for phenotypic drug susceptibility testing.

Antimicrobial agents and chemotherapy - 6 Aug 2025

Ismail Nabila, Sirgel Frik, Omar Shaheed Vally, Omar Shatha, de Kock Marianna, Spies Claudia, Folkerts Megan, Theron Grant, Engelthaler Dave, Metcalfe John, Warren Robin M

Abstract excerpt

Phenotypic drug susceptibility testing (pDST) remains a widely used standard for determination of resistance for several drugs for the Mycobacterium tuberculosis complex. Next-generation sequencing technologies can identify heteroresistant populations at low frequencies, but little is known about the impact of heteroresistance on bedaquiline (BDQ) pDST results. We simulated heteroresistance using in...

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PMID: 40689761
DOI: 10.1128/aac.00356-25
PMCID: PMC12326995

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