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Article

Detection of Pyrazinamide Heteroresistance in Mycobacterium tuberculosis.

Antimicrobial agents and chemotherapy - 17 Aug 2021

Werngren Jim, Mansjö Mikael, Glader Mikaela, Hoffner Sven, Davies Forsman Lina

Abstract excerpt

Heteroresistance is defined as the coexistence of both susceptible and resistant bacteria in a bacterial population. Previously published data show that it may occur in 9 to 57% of Mycobacterium tuberculosis isolates for various drugs. Pyrazinamide (PZA) is an important first-line drug used for treatment of both drug-susceptible and PZA-susceptible multidrug-resistant TB. Clinical PZA resistance is defined as a...

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Identifiers

PMID: 34181476
DOI: 10.1128/AAC.00720-21
PMCID: PMC8370246

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