Article
Genotype-Phenotype Characterization of Serial Mycobacterium tuberculosis Isolates in Bedaquiline-Resistant Tuberculosis.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 17 Feb 2024
Brown Tyler S, Tang Linrui, Omar Shaheed Vally, Joseph Lavania, Meintjes Graeme, Maartens Gary, Wasserman Sean, Shah N Sarita, Farhat Maha R, Gandhi Neel R, Ismail Nazir, Brust James C M, Mathema Barun
Abstract excerpt
BACKGROUND: Emerging resistance to bedaquiline (BDQ) threatens to undermine advances in the treatment of drug-resistant tuberculosis (DRTB). Characterizing serial Mycobacterium tuberculosis (Mtb) isolates collected during BDQ-based treatment can provide insights into the etiologies of BDQ resistance in this important group of DRTB patients. METHODS: We measured mycobacteria growth indicator tube (MGIT)-based BDQ...
Topics
- Humans
- Mycobacterium tuberculosis
- Antitubercular Agents
- Diarylquinolines
- Tuberculosis
- Tuberculosis, Multidrug-Resistant
- Genotype
- Phenotype
- Microbial Sensitivity Tests