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Article

Opportunities and limitations of genomics for diagnosing bedaquiline-resistant tuberculosis: an individual isolate meta-analysis

2023-05-05

Abstract excerpt

<h4>Background</h4> Clinical bedaquiline resistance predominantly involves mutations in mmpR5 ( Rv0678 ). However, mmpR5 resistance-associated variants (RAVs) have a variable relationship with phenotypic M. tuberculosis resistance. We performed a systematic review to (1) assess the maximal sensitivity of sequencing bedaquiline resistance-associated genes and (2) evaluate the association between RAVs and phenotypic...

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Literature Corpus work
0e25b742-1015-543c-88ad-09ec2b35d6b8
DOI
10.1101/2023.05.04.23289023
Open publication

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Opportunities and limitations of genomics for diagnosing bedaquiline-resistant tuberculosis: an individual isolate meta-analysisDOI 10.1101/2023.05.04.23289023
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