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Article

Opportunities and limitations of genomics for diagnosing bedaquiline-resistant tuberculosis: a systematic review and individual isolate meta-analysis.

The Lancet. Microbe - 1 Feb 2024

Nimmo Camus, Bionghi Neda, Cummings Matthew J, Perumal Rubeshan, Hopson Madeleine, Al Jubaer Shamim, Naidoo Kogieleum, Wolf Allison, Mathema Barun, Larsen Michelle H, O'Donnell Max

Abstract excerpt

BACKGROUND: Clinical bedaquiline resistance predominantly involves mutations in mmpR5 (Rv0678). However, mmpR5 resistance-associated variants (RAVs) have a variable relationship with phenotypic Mycobacterium tuberculosis resistance. We did a systematic review to assess the maximal sensitivity of sequencing bedaquiline resistance-associated genes and evaluate the association between RAVs and phenotypic resistance,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38215766
DOI: 10.1016/S2666-5247(23)00317-8
PMCID: PMC11072239

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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