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Article

We Are Underprepared for Bedaquiline Resistance: A Call for Clinical and Programmatic Readiness.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 8 Jul 2026

Cross Gail Brenda, Walker Harry N, Hasan Tasnim, Berry Catherine

Abstract excerpt

Bedaquiline has transformed the treatment of multidrug-resistant tuberculosis (MDR-TB). However, bedaquiline resistance now threatens these gains. Emerging surveillance data demonstrate both baseline and acquired resistance across high-burden settings, with bedaquiline-resistant disease associated with poor clinical outcomes, high mortality, and growing evidence of transmission. In this Perspective, we examine...

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PMID: 41498255
DOI: 10.1093/cid/ciag008
PMCID: PMC13341242

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